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Articles (45)
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Development of an in vitro drug release assay that accurately predicts in vivo drug retention for liposome-based delivery systems

Jennifer A Shabbits, Gigi N.C Chiu, Lawrence D Mayer

Journal:

Journal of Controlled Release

Année:

2002

Langue:

english

Fichier:

PDF, 477 KB

english, 2002

Ex Vivo Expansion of SCID-Repopulating CD34 + CD90 + CD49f + Hematopoietic Stem & Progenitor Cells From Non-Enriched Human Umbilical Cord Blood with Novel Azole-Based Small Molecules

Bari, Sudipto, Zhong, Qixing, Fan, Xiubo, Poon, Zhiyong, Lim, Alvin Soon Tiong, Lim, Tse Hui, Dighe, Niraja, Li, Shang, Chiu, Gigi Ngar Chee, Chai, Christina Li Lin, Hwang, William Ying Khee

Journal:

Biology of Blood and Marrow Transplantation

Année:

2018

Langue:

english

Fichier:

PDF, 211 KB

english, 2018

Clinical Applications of Carbon Nanomaterials in Diagnostics and Therapy

Loh, Kian Ping, Ho, Dean, Chiu, Gigi Ngar Chee, Leong, David Tai, Pastorin, Giorgia, Chow, Edward Kai-Hua

Journal:

Advanced Materials

Année:

2018

Langue:

english

Fichier:

PDF, 3.93 MB

english, 2018

ChemInform Abstract: Fused Heterocyclic Systems with s-Triazine Ring. Part 14. Synthesis and Heterocyclizations of 3,4-Dihydroquinazolin-2-yl Guanidine in the Search of New Anticancer Agents.

Anton V. Dolzhenko, Mi Chelle Foo, Bee Jen Tan, Anna V. Dolzhenko, Gigi Ngar Chee Chiu, Wai Keung Chui

Journal:

ChemInform

Année:

2009

Langue:

english

Fichier:

PDF, 34 KB

english, 2009

The functional roles of poly(ethylene glycol)-lipid and lysolipid in the drug retention and release from lysolipid-containing thermosensitive liposomes in vitro and in vivo

Brian Banno, Ludger M. Ickenstein, Gigi N.C. Chiu, Marcel B. Bally, Jenifer Thewalt, Elana Brief, Ellen K. Wasan

Journal:

Journal of Pharmaceutical Sciences

Année:

2010

Langue:

english

Fichier:

PDF, 359 KB

english, 2010

Use of a passive equilibration methodology to encapsulate cisplatin into preformed thermosensitive liposomes

Janet Woo, Gigi N.C. Chiu, Göran Karlsson, Ellen Wasan, Ludger Ickenstein, Katarina Edwards, Marcel B. Bally

Journal:

International Journal of Pharmaceutics

Année:

2008

Langue:

english

Fichier:

PDF, 937 KB

english, 2008

Synthesis and biological activity of fluorinated 7-aryl-2-pyridyl-6,7-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-amines

Anton V. Dolzhenko, Bee Jen Tan, Anna V. Dolzhenko, Gigi Ngar Chee Chiu, Wai Keung Chui

Journal:

Journal of Fluorine Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 315 KB

english, 2008

Lyophilization of cholesterol-free PEGylated liposomes and its impact on drug loading by passive equilibration

Anumita Chaudhury, Surajit Das, Ronald F.S. Lee, Kuan-Boone Tan, Wai-Kiong Ng, Reginald B.H. Tan, Gigi N.C. Chiu

Journal:

International Journal of Pharmaceutics

Année:

2012

Langue:

english

Fichier:

PDF, 966 KB

english, 2012

Encapsulation of doxorubicin into thermosensitive liposomes via complexation with the transition metal manganese

Gigi N.C. Chiu, Sheela A. Abraham, Ludger M. Ickenstein, Rebecca Ng, Göran Karlsson, Katarina Edwards, Ellen K. Wasan, Marcel B. Bally

Journal:

Journal of Controlled Release

Année:

2005

Langue:

english

Fichier:

PDF, 358 KB

english, 2005

In vivo efficacy of a novel liposomal formulation of safingol in the treatment of acute myeloid leukemia

Kuan-Boone Tan, Leong-Uung Ling, Ralph M. Bunte, Wee-Joo Chng, Gigi N.C. Chiu

Journal:

Journal of Controlled Release

Année:

2012

Langue:

english

Fichier:

PDF, 860 KB

english, 2012

Liposome formulation of co-encapsulated vincristine and quercetin enhanced antitumor activity in a trastuzumab-insensitive breast tumor xenograft model

Man-Yi Wong, Gigi N.C. Chiu

Journal:

Nanomedicine: Nanotechnology, Biology and Medicine

Année:

2011

Langue:

english

Fichier:

PDF, 423 KB

english, 2011

Selective protein interactions with phosphatidylserine containing liposomes alter the steric stabilization properties of poly(ethylene glycol)

Gigi N.C. Chiu, Marcel B. Bally, Lawrence D. Mayer

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

2001

Langue:

english

Fichier:

PDF, 362 KB

english, 2001

Effects of phosphatidylserine on membrane incorporation and surface protection properties of exchangeable poly(ethylene glycol)-conjugated lipids

Gigi N.C Chiu, Marcel B Bally, Lawrence D Mayer

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

2002

Langue:

english

Fichier:

PDF, 365 KB

english, 2002

Application of purging biotinylated liposomes from plasma to elucidate influx and efflux processes associated with accumulation of liposomes in solid tumors

Vincent W.H. Fung, Gigi N.C. Chiu, Lawrence D. Mayer

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

2003

Langue:

english

Fichier:

PDF, 201 KB

english, 2003

Targeting of antibody conjugated, phosphatidylserine-containing liposomes to vascular cell adhesion molecule 1 for controlled thrombogenesis

Gigi N.C. Chiu, Marcel B. Bally, Lawrence D. Mayer

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

2003

Langue:

english

Fichier:

PDF, 176 KB

english, 2003

Potent therapeutic activity of folate receptor-targeted liposomal carboplatin in the localized treatment of intraperitoneally grown human ovarian tumor xenograft

Chiu, Gigi, Chaudhury,, Das,, Bunte,

Journal:

International Journal of Nanomedicine

Année:

2012

Langue:

english

Fichier:

PDF, 4.82 MB

english, 2012

Role of oxidative stress, endoplasmic reticulum stress and ERK activation in triptolide-induced apoptosis

Chiu, Gigi

Journal:

International Journal of Oncology

Année:

2013

Langue:

english

Fichier:

PDF, 786 KB

english, 2013

Multivalent rituximab lipid nanoparticles as improved lymphoma therapies: indirect mechanisms of action and in vivo activity

Popov, Jesse, Kapanen, Anita I, Turner, Christopher, Ng, Rebecca, Tucker, Catherine, Chiu, Gigi, Klasa, Richard, Bally, Marcel B, Chikh, Ghania

Journal:

Nanomedicine

Année:

2011

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2011

A structure–activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5]triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities

Bera, Hriday, Tan, Bee Jen, Sun, Lingyi, Dolzhenko, Anton V., Chui, Wai-Keung, Chiu, Gigi Nagar Chee

Journal:

European Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 651 KB

english, 2013

Liposome co-encapsulation of synergistic combination of irinotecan and doxorubicin for the treatment of intraperitoneally grown ovarian tumor xenograft

Shaikh, Ishaque M., Tan, Kuan-Boone, Chaudhury, Anumita, Liu, Yuanjie, Tan, Bee-Jen, Tan, Bernice M.J., Chiu, Gigi N.C.

Journal:

Journal of Controlled Release

Année:

2013

Langue:

english

Fichier:

PDF, 1.43 MB

english, 2013

Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1,5-a][1,3,5]triazines as thymidine phosphorylase inhibitors

Sun, Lingyi, Li, Jiarong, Bera, Hriday, Dolzhenko, Anton V., Chiu, Gigi N.C., Chui, Wai Keung

Journal:

European Journal of Medicinal Chemistry

Année:

2013

Langue:

english

Fichier:

PDF, 1.77 MB

english, 2013

Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: Synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II

Bera, Hriday, Ojha, Probir kumar, Tan, Bee Jen, Sun, Lingyi, Dolzhenko, Anton V., Chui, Wai-Keung, Chiu, Gigi Ngar Chee

Journal:

European Journal of Medicinal Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 1.21 MB

english, 2014

DEVELOPMENT AND CHARACTERIZATION OF A NANOCARRIER FOR QUERCETIN

WONG, MAN-YI, CHIU, GIGI N. C.

Journal:

International Journal of Nanoscience

Année:

2009

Langue:

english

Fichier:

PDF, 148 KB

english, 2009

Liposomes as sterile preparations and limitations of sterilisation techniques in liposomal manufacturing

Toh, Ming-Ren, Chiu, Gigi N.C.

Journal:

Asian Journal of Pharmaceutical Sciences

Année:

2013

Langue:

english

Fichier:

PDF, 520 KB

english, 2013

Dual-Functionalized PAMAM Dendrimers with Improved P-Glycoprotein Inhibition and Tight Junction Modulating Effect

Liu, Yuanjie, Chiu, Gigi N. C.

Journal:

Biomacromolecules

Année:

2013

Langue:

english

Fichier:

PDF, 2.76 MB

english, 2013

Intercellular cytosolic transfer correlates with mesenchymal stromal cell rescue of umbilical cord blood cell viability during ex vivo expansion

Chu, Pat P.Y., Bari, Sudipto, Fan, Xiubo, Gay, Florence P.H., Ang, Justina M.L., Chiu, Gigi N.C., Lim, Sai K., Hwang, William Y.K.

Journal:

Cytotherapy

Année:

2012

Langue:

english

Fichier:

PDF, 1.01 MB

english, 2012

Protective role of functionalized single walled carbon nanotubes enhance ex vivo expansion of hematopoietic stem and progenitor cells in human umbilical cord blood

Bari, Sudipto, Chu, Pat Pak Yan, Lim, Andrea, Fan, Xiubo, Gay, Florence Pik Hoon, Bunte, Ralph Milford, Lim, Tony Kiat Hon, Li, Shang, Chiu, Gigi Ngar Chee, Hwang, William Ying Khee

Journal:

Nanomedicine: Nanotechnology, Biology and Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 4.18 MB

english, 2013

Liposomal codelivery of a synergistic combination of bioactive lipids in the treatment of acute myeloid leukemia

Tan, Kuan-Boone, Ling, Leong-Uung, Bunte, Ralph M, Chng, Wee-Joo, Chiu, Gigi NC

Journal:

Nanomedicine

Année:

2014

Langue:

english

Fichier:

PDF, 5.67 MB

english, 2014

Synthesis and biological activity of fluorinated 7-benzylamino-2-phenyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines

Dolzhenko, Anna V., Tan, Bee Jen, Chiu, Gigi Ngar Chee, Chui, Wai Keung, Dolzhenko, Anton V.

Journal:

Journal of Fluorine Chemistry

Année:

2015

Langue:

english

Fichier:

PDF, 401 KB

english, 2015

Optimization and Therapeutic Activity of Liposome-Conjugated Monoclonal Antibodies Against the ErbB family of Receptor Tyrosine Kinases: First Step in the Development of Therapeutic Antibody/Liposomal Anticancer Drug Combinations

N.C. Chiu, Gigi, O. Harasym, Troy, G. Tardi, Paul, B. Bally, Marcel, N. Waterhouse, Dawn

Journal:

Letters in Drug Design & Discovery

Année:

2006

Langue:

english

Fichier:

PDF, 199 KB

english, 2006

Mitochondrial superoxide reduction & cytokine secretion skewing by carbon nanotube scaffolds enhance ex vivo expansion of human cord blood hematopoietic progenitors

Bari, Sudipto, Chu, Pat Pak Yan, Lim, Andrea, Fan, Xiubo, Bunte, Ralph Milford, Li, Shang, Ghosh, Sujoy, Chiu, Gigi Ngar Chee, Hwang, William Ying Khee

Journal:

Nanomedicine: Nanotechnology, Biology and Medicine

Année:

2015

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2015

Lipid-dendrimer hybrid nanosystem as a novel delivery system for paclitaxel to treat ovarian cancer

Liu, Yuanjie, Ng, Yiwei, Toh, Ming R., Chiu, Gigi N.C.

Journal:

Journal of Controlled Release

Année:

2015

Langue:

english

Fichier:

PDF, 1.17 MB

english, 2015

Lipid-Based Nanoparticulate Systems for the Delivery of Anti-Cancer Drug Cocktails: Implications on Pharmacokinetics and Drug Toxicities

Chiu, Gigi, Wong, Man-Yi, Ling, Leong-Uung, Shaikh, Ishaque, Tan, Kuan-Boone, Chaudhury, Anumita, Tan, Bee-Jen

Journal:

Current Drug Metabolism

Année:

2009

Langue:

english

Fichier:

PDF, 297 KB

english, 2009

Dual-functionalized poly(amidoamine) dendrimers with poly(ethylene glycol) conjugation and thiolation improved blood compatibility

Liu, Yuanjie, Pang, Yanzhen, Toh, Ming R., Chiu, Gigi N. C.

Journal:

Journal of Pharmacy and Pharmacology

Année:

2015

Langue:

english

Fichier:

PDF, 894 KB

Loh, Kian Ping, Ho, Dean, Chiu, Gigi Ngar Chee, Leong, David Tai, Pastorin, Giorgia, Chow, Edward Kai-Hua

Journal:

Advanced Materials

Année:

2018

Fichier:

PDF, 3.93 MB

2018

Functionalized carbon nanomaterials: exploring the interactions with Caco-2 cells for potential oral drug delivery

Chiu, Gigi, Coyuco,, Liu,, Tan,

Journal:

International Journal of Nanomedicine

Année:

2011

Langue:

english

Fichier:

PDF, 2.30 MB

english, 2011